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Antifungal Activity of Amphotericin B-Loaded Nanoparticles

Hasan Mohammad Asghari 1 and Shahram Nanekarani 2
1. Department of Laboratory Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2. Department of Animal Science, Borujerd Branch, Islamic Azad University, Borujerd, Iran
Abstract—The purpose of this discussion was to prepare and appraise invivo and invitro effect of the spray-dried Amphotericin B (AmB) -loaded nanospheres. The spray-dried nanospheres were prepared by using aerosol and Am.B entrapment effect was measured by HPLC method. Minimum inhibitory concentration (MIC) of AmB-loaded nanospheres against Candida albicans (ATCC 90028) was defined by using micro dilution method and its in vitro haemolytic effect and antifungal effect on infected rabbits was also analyzed. The MIC of Am.B-loaded nanospheres against C. albicans compared to the free antibiotic was lower significantly. Invivo testing indicated that AmB-loaded nanospheres have a stronger protective effect against candidiasis compared to the free AmB. Results of this discussion indicate that prepared spray-dried Am.B-loaded nanospheres would be a good choice for the therapy of mycosis because of low toxicity and high consistency and effect. By developing this method can greatly reduce the side effects of antibiotics in human body. 
Index Terms—amphotericin B, nanosphere, antifungal activity, candidiasis

Cite: Hasan Mohammad Asghari and Shahram Nanekarani, "Antifungal Activity of Amphotericin B-Loaded Nanoparticles," Journal of Advanced Agricultural Technologies, Vol. 3, No. 1, pp. 26-29, March 2016. Doi: 10.18178/joaat.3.1.26-29
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